The firm's native voice over internet protocol (VoIP) application - Skype for iPhone - will be available for download from Apples iTune store on Tuesday.
The new service will allow users to make free calls to Skype users, but will charge for calls to other numbers.
The UK's first Skype capable handset was launched by Mobile operator 3 on 2 November 2007.
Rival applications from Fring and TruPhone are already available for the iPhone.
Unlike traditional mobile calls, which are transmitted over a cellular network, VoIP turns your voice into data and sends it over the internet using a wi-fi network.
